Alumni

  • Chang Geon Chung, Ph.D.
  • Ph.D. 2012-2021

introduce

Education:

Illinois Wesleyan University (B.S.)

Major: Psychology

DGIST (Ph.D.)

Major: Brain & Cognitive Sciences

 

Research Projects:

Cellular and molecular mechanisms underlying early neuropathy of neurodegenerative diseases and aging

 

Publications:

Jang, H.J., Le, M.U.T., Park, J.H., Chung, C.G., Shon, J.G., Lee, G.S., Moon, J.H., Lee, S.B., Choi, J.S., Lee, T.G., and Yoon, S. (2021) Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging of Phospholipid Changes in a Drosophila Model of Early Amyotrophic Lateral Sclerosis. J. Am. Soc. Mass Spectrom. Doi: 10.1021/jasms.1c00167.

Kim, E.S.*Chung, C.G.*, Park, J.H.*, Ko, B.S.*, Park, S.S., Kim, Y.H., Cha, I.J., Kim, J., Ha, C.M., Kim, H.J., and Lee, S.B. (2021) C9orf72-associated arginine-rich dipeptide repeats induce RNA-dependent nuclear accumulation of Staufen in neurons. Hum. Mol. Genet. ddab089. doi: 10.1093/hmg/ddab089. (*: co-first author)

Park, J.H.*, Chung, C.G.*, Park, S.S., Lee, D., Kim, K.M., Jeong, Y., Kim, E.S., Cho, J.H., Jeon, Y.-M., Shen, C.J., Kim, H.-J., Hwang, D., and Lee, S.B. (2020) Cytosolic calcium regulates cytoplasmic accumulation of TDP-43 through Calpain-A and Importin a3. eLife 9:e60132. doi: 10.7554/eLife.60132. (*: co-first author).

Lee, D., Jo, M.G., Kim, S.Y., Chung, C.G.*, and Lee, S.B.* (2020) Dietary antioxidants and the mitochondrial quality control: Their potential roles in Parkinson's disease treatment. Antioxidants 9:E1056. doi: 10.3390/antiox9111056. (*: co-corresponding author)

Chung, C.G.*, Park, S.S.*, Park, J.H.*, and Lee, S.B. (2020) Dysregulated plasma membrane turnover underlying dendritic pathology in neurodegenerative diseases. Front. Cell Neurosci. 14:556461. (*: co-first author)

Cha, I.J.*Lee, D.*, Park, S.S., Chung, C.G., Kim, S.Y., Jo,M.G., Kim, S.Y., Lee, B.-H., Lee, Y.-S., and Lee, S.B. (2020) Ataxin-2 dysregulation triggers a compensatory Fragile X mental retardation protein decrease in Drosophila C4da neurons. Mol. Cells 43:870-879. (*: co-first author)

Park, J.H.*, Chung, C.G.*, Seo, J., Lee, B.H., Lee, Y.S., Kweon, J.H., and Lee, S.B. (2020) C9orf72-Associated Arginine-Rich Dipeptide Repeat Proteins Reduce the Number of Golgi Outposts and Dendritic Branches in Drosophila Neurons. Mol. Cells 43:821-839. Doi: 10.14348/molcells.2020.0130. (*: co-first author)

Kim, Y.Y., Yoon, J.H., Um, J.H., Jeong, D.J., Shin, D.J., Hong, Y.B., Kim, J.K., Kim, D.H., Kim, C., Chung, C.G., Lee, S.B., Koh, H., and Yun, J. (2020) PINK1 alleviates thermal hypersensitivity in a paclitaxel-induced Drosophila model of peripheral neuropathy. PLoS One 15:e0239126. 

Kim, E.S.*Chung, C.G.*, Kim, Y.H., Cha, I.J., Park, J.H., Kim, J., Ha, C.M., Kim, H.-J., and Lee,S.B. (2019) C9orf72-associated arginine-rich dipeptide repeats induce RNA-dependent accumulation of Staufen in nucleus. bioRxiv doi: https://doi.org/10.1101/773796. (*: co-first author)

Chung, C.G., Lee, H., and  Lee, S.B. (2018) Mechanisms of protein toxicity in neurodegenerative diseases. Cell. Mol. Life Sci. 75:3159-3180. 

Chung, C.G.*, Kwon, M.J.*, Jeon, K.H.*, Hyeon, D.Y.*, Han, M.H., Park, J.H., Cha, I.J., Cho, J.H., Kim, K., Rho, S., Kim, G.R., Jeong, H., Lee, J.W., Kim, T., Kim, K., Kim, K.P., Ehlers, M.D., Hwang, D., and Lee, S.B. (2017)  Golgi outpost synthesis impaired by toxic polyglutamine proteins contributes to dendritic pathology in neurons. Cell Reports 20:356-369. (*: co-first author) * Recommended in F1000 prime: https://f1000.com/prime/727800724 * Selected as BRIC 한빛사 추천논문: http://www.ibric.org/myboard/read.php?Board=hbs_treatise&id=55474&idauthorid=299&ttype=2

Jeon, Y.M., Lee, S., Kim, S., Kwon, Y., Chung, C.G., Lee, S., Lee, S.B., and Kim, H.J. (2017) Neuroprotective effects of protein tyrosine phosphatase 1B inhibition against ER stress-induced toxicity. Mol. Cells 40:280-290.

Cho, J.H., Park, J.H., Chung, C.G., Shim, H.-J., Jeon, K.H., Yu, S.-W., and Lee, S.B. (2015) BBRC pii: S0006-291X(15)00901-8. doi: 10.1016/j.bbrc.2015.05.006

Chung, C.G., and Lee. S.B. (2014) Regulation of Mitochondrial Calcium through the MCU complex. KSMCB Webzine (www.ksmcb.or.kr/webzine/webzine.html).



Honors & Awards:

2021 Best Presentation Award at the YSP of 2021 KSBMB

2021 Selected as a speaker at the Young Scientist Program (YSP) of 2021 KSBMB

2020 Granted for domestic Post-doc training supported by Korean government

2017 DGIST outstanding researcher award


Thesis title:

Characterization of the role of Golgi outposts in dendritic pathology caused by polyglutamine toxicity in neurons